- Title
- No reliable association between runs of homozygosity and schizophrenia in a well-powered replication study
- Creator
- Johnson, Emma C.; Bjelland, Douglas W.; Genovese, Giulio; Heilmann-Heimbach, Stefanie; Herms, Stefan; Hoffman, Per; Maier, Wolfgang; Mattheisen, Manuel; Morris, Derek; Mowry, Bryan; Müller-Mhysok, Betram; Neale, Benjamin; Howrigan, Daniel P.; Schizophrenia Working Group of the Psychiatric Genomics Consortium,; Carr, Vaughan J.; Henskens , Frans A.; Loughland, Carmel M.; Schall, Ulrich; Scott, Rodney J.; Abdellaoui, Abdel; Breen, Gerome; Borglum, Anders; Cichon, Sven; Degenhardt, Franziska; Forstner, Andreas J.; Frank, Josef
- Relation
- PLoS Genetics Vol. 12, Issue 10
- Publisher Link
- http://dx.doi.org/10.1371/journal.pgen.1006343
- Publisher
- Public Library of Science (PLoS)
- Resource Type
- journal article
- Date
- 2016
- Description
- It is well known that inbreeding increases the risk of recessive monogenic diseases, but it is less certain whether it contributes to the etiology of complex diseases such as schizophrenia. One way to estimate the effects of inbreeding is to examine the association between disease diagnosis and genome-wide autozygosity estimated using runs of homozygosity (ROH) in genome-wide single nucleotide polymorphism arrays. Using data for schizophrenia from the Psychiatric Genomics Consortium (n = 21,868), Keller et al. (2012) estimated that the odds of developing schizophrenia increased by approximately 17% for every additional percent of the genome that is autozygous (β = 16.1, CI(β) = [6.93, 25.7], Z = 3.44, p = 0.0006). Here we describe replication results from 22 independent schizophrenia case-control datasets from the Psychiatric Genomics Consortium (n = 39,830). Using the same ROH calling thresholds and procedures as Keller et al. (2012), we were unable to replicate the significant association between ROH burden and schizophrenia in the independent PGC phase II data, although the effect was in the predicted direction, and the combined (original + replication) dataset yielded an attenuated but significant relationship between Froh and schizophrenia (β = 4.86,CI(β) = [0.90,8.83],Z = 2.40,p = 0.02). Since Keller et al. (2012), several studies reported inconsistent association of ROH burden with complex traits, particularly in case-control data. These conflicting results might suggest that the effects of autozygosity are confounded by various factors, such as socioeconomic status, education, urbanicity, and religiosity, which may be associated with both real inbreeding and the outcome measures of interest.
- Subject
- homozygosity; schizophrenia; mental health; mental illness; inbreeding
- Identifier
- http://hdl.handle.net/1959.13/1336500
- Identifier
- uon:27630
- Identifier
- ISSN:1553-7404
- Rights
- © 2016 Johnson et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
- Language
- eng
- Full Text
- Reviewed
- Hits: 27900
- Visitors: 28108
- Downloads: 369
| Thumbnail | File | Description | Size | Format | |||
|---|---|---|---|---|---|---|---|
| View Details Download | ATTACHMENT02 | Publisher version (open access) | 1 MB | Adobe Acrobat PDF | View Details Download |